Estudo dos efeitos cardiorrespiratório, hemogasométrico e sedativo da infusão de detomidina isoladamente e associada à morfina em muares na posição quadrupedal

Abstract

There are few studies evaluating the effects of application of detomidine followed by continuous infusion comparing with the association of this sedative with morphine in mules. Present study aimed to evaluate the cardiorespiratory, sedative and arterial gasometric effects of these two treatments over time. Six animals were used applying morphine alone and associated with detomidine, at different times, the treatments being carried out blindly and randomly. A bolus of detomidine (10.0 μg/kg) followed by yours continuous infusion (20.0 μg/kg/hour) was used in the other group, and in the other group detomidine (10.0 μg/kg) added morphine (0.1 mg/kg) of continuous infusion of detomidine (20.0 μg/kg/hour) associated with morphine (0.1 mg/kg/hour). In both treatments, cardiorespiratory depression accompanied by an increase in systolic blood pressure was observed, with the presence of atrioventricular block in all animals. The sedative effect was shown to be very pronounced, however, only a significant difference in touch sensitivity was observed between the groups, suggesting that the group where it was associated with morphine obtained a greater loss of sensitivity for a longer time. The reduction in oxygen partial pressure and increase in carbon dioxide partial pressure observed occurred due to respiratory depression, with a possibly compensatory increase in sodium bicarbonate.