Caracterização clínica, histopatológica e morfométrica dos sarcomas de tecidos moles em cães e impacto no prognóstico

Abstract

Soft tissues sarcomas (STS) represents a heterogeneous group of tumors with histological characteristics and similar biological behavior. Histological grade is the most important prognostic factor in STS. Higher grades are associated with more aggressive biological behavior, higher rates of local recurrence, distant metastases and shorter disease-free intervals. Thus, grading offers a better direction to therapy. Metastasis rate are more associated with higher grades scores than the histopathological type of the tumor. The purpose of this study was to add more parameters for STS classification in order to promote a more reliable diagnosis and therefore a more appropriate treatment for each tumor. It was analyzed 30 cases of STM treated at the UVV Veterinary Hospital. Clinical, histopathological and morphometric parameters of these tumors was correlated. There were a positive correlation of the clinical aspects of the tumor and the histopathologyc characteristics in Spearmann test. Moreover, it was observed a greater nucleus-cytoplasm relationship and the number of vessels according to the degree of malignancy for subcutaneous tumors. It was concluded that the morphometry was useful in the evaluation of the STS, representing an additional tool for characterize and better understand the biological behavior of STS. However, further studies are needed to validate this technique.